This project seeks to support the realization of the sexual and reproductive health and rights (SRHR) of adolescent girls and young women (AGYW) 10-24 years old in Katavi region. The Adolescent Girls’ Health and Rights in Tanzania project aims to ensure this support is tailored to the different needs of these AGYW. Project activities include: (1) building AGYW’s individual and collective agency by increasing their access to SRHR, sexual and gender-based violence (SGBV) prevention, menstrual health and hygiene, infection prevention and control, and nutrition information and services; (2) empowering AGYW through increased social capital, life skills, capacities and financial capital; (3) prioritizing the participation of marginalized girls’, including out-of-school girls, pregnant girls, adolescent mothers, adolescents living with HIV, disabled girls and hard to reach, disadvantaged girls belonging to nomadic groups, in project activities; (4) building a more resilient, accountable and adolescent-responsive health system able to absorb shocks like the COVID-19 pandemic; (5) supporting stakeholders, particularly women’s rights organizations and youth-led organizations; (6) improving the quality of care through gender-transformative training and technical assistance for health providers to strengthen the provision of gender- and adolescent-responsive and inclusive, integrated and innovative SRHR services and SGBV protection services; and (7) providing support for AGYW by enhancing community, school, health facility and governmental capacity, infrastructure, planning and management. The project expects to directly reach 147,615 AGYW (roughly 80% of the region’s projected girls aged 10-24 years, including 60,121 girls 10-14 years of age, 56,076 adolescents 15-19 years of age and 31,418 young women 20-24 years of age), 1,592 women and 1,665 men intermediaries beneficiaries (including community health care workers, youth peer educators, teachers, local government employees, heads of school and youth, gender, education and change facilitators) and 289,397 girls and women and 424,978 boys and men as indirect beneficiaries. In addition, the project seeks to improve the capacity and conditions in Katavi region’s five hospitals, 14 health centres and 64 village-level clinics. All health facilities will receive training for staff and 40 health facilities will benefit from additional supplies and upgrades.